ICAM1 and neoplasm: Wheat germ extract has been reported to have an influential role in enhancing the activity of the immune system, such as stimulating NK cell activity by reducing the expression of MHC I molecules; by stimulating TNF secretion of the macrophages; and by increasing ICAM 1 molecule expression on the vascular endothelial cells, which leads to the apoptosis of tumor cells as a consequence [47].