CXCL12 and neoplasm: CAFs contribute to the generation of an immune suppressing TME through polarization of macrophages to an M2 phenotype; intra-tumoral recruitment of N2 neutrophils; secretion of pro-tumor cytokines TGF-β, IL-6, and C-X-C motif chemokine 12 (CXCL12); and exclusion of T cells from interacting with tumor cells via matrix remodeling [87].