In preclinical models, administration of monoclonal antibodies targeting the TWEAK/Fn14 interaction led to tumor shrinkage and enhancement of the host antitumor immune response by attracting immune cells, particularly CD45+ memory cells, within the TME through Monocyte Chemoattractant Protein-1 (MCP-1) activation [24]. The gene discussed is CCL2; the disease is neoplasm.