POMC and autism: Nevertheless, alterations on the level of 17-alpha Hydroxylase and 17/20 Lyase and, in addition, the CRH-ACTH System are in line with the findings that the average increase of metabolites measured prior to 17-alpha Hydroxylase activity (TH-Corticosterone, 5α-TH-Corticosterone and TH-11β-DH-Corticosterone) is less increased in affected children with autism as compared to the increase of Cortisol, indicating, in addition, stimulation by the CRH-ACTH system (Figure 4).