Talmud et al. [97] analyzed 2708 healthy middle-aged European men and found that smokers with LPL Asp9Asn polymorphism had a 10.4-fold higher risk of IHD/CAD compared with non-smoker individuals who do not carry that mutation; individuals who smoked but did not carry the allele had a 1.6 times higher risk than non-smokers [97]. This evidence concerns the gene LPL and myocardial ischemia.