The polymorphism of the ITGB2 gene (located on chromosome 21q22.3) encoding glycoprotein IIb (GPIIb-beta-2 integrin) and the ITGB3 gene (located on chromosome 17q21.32) encoding glycoprotein IIIa (GPIIIa-integrin beta-3) were analyzed, in connection with a possible causal association in patients with CAD/MI [16,122]. Here, ITGB3 is linked to coronary artery disorder.