Zhang et al. [128] performed a meta-analysis that included 13 studies (10,801 cases and 9381 controls) in which they analyzed the association between SNP polymorphism in genes encoding thrombospondin-1 (THBS1-located on chromosome 15q14), thrombospondin-2 (THBS2-located on chromosome 6q27 and thrombospondin-4 (THBS4-located on chromosome 5q14.1) and the risk of CAD. Here, THBS4 is linked to coronary artery disorder.