MTHFR and myocardial ischemia: The European population with the MTHFR TT genotype had a significantly higher risk of IHD (odds ratio 1.14, 1.01–1.28) compared with North Americans in whom no increase in risk for the same genotype was observed (odds ratio 0.87, 0.73–1.05), the differences being partially explained by the different dietary intake of folates in the two analyzed populations [133].