In the meta-analysis by Liang et al. [126], which analyzed the results of 53 studies, it is argued that PAI-1 4G/5G polymorphism may contribute to individual susceptibility to CAD, but to further evaluate gene-gene and gene-environment interactions on PAI-1 gene 4G/5G polymorphism and CAD, more studies are needed in selected populations, from different environmental backgrounds or where different risk factors are present [126]. Here, SERPINE1 is linked to coronary artery disorder.