Mutations of genes encoding the LDL receptor (LDLR), apolipoprotein B-100 (ApoB-100), an LDL-C receptor ligand, and proprotein convertase, subtilisin/kexin-type 9 (PCSK9) cause familial hypercholesterolemia type 1 (FH), (OMIM, 606,945), an autosomal dominant disorder [16]. This evidence concerns the gene LDLR and familial hyperaldosteronism.