In another study, the analysis of a group of 100 unrelated CAD patients using WES identified the presence in seven of them of four different CYP27A1 allelic variants (p.Arg14Gly, p.Arg26Lys, p.Ala27Arg and p.Val86Met) that could cause CAD [65]. The gene discussed is CYP27A1; the disease is coronary artery disorder.