Two allelic variants of the APOB gene: C10580G (p.Arg3527Gln) [20] and C10800T (p.Arg3531Cys) [21] have been associated with decreased affinity for LDLR, leading to familial hypercholesterolemia type 2 (FHCL2) (OMIM 144,010) also called familial defective apolipoprotein B-100 (FDB), an autosomal dominant genetic disorder associated with hyperlipidemia and increased risk of early atherosclerosis [16]. Here, APOB is linked to atherosclerosis.