In a study by Jin et al. during a 4-week randomised controlled double-blinded beverage intervention study, it was reported that reduction in dietary fructose in Hispanic American adolescents with NAFLD improved several plasma markers associated with metabolic syndrome (e.g., adipose insulin sensitivity, high-sensitivity C-reactive protein and low-density lipoprotein oxidation) [132]. This evidence concerns the gene INS and metabolic dysfunction-associated steatotic liver disease.