The most common tumor suppressor genes in MM are the family with sequence similarity 46, member c (FAM46C), exosome complex exonuclease (DIS3), CYLD lysine 63 deubiquitinase (CYLD), baculoviral IAP repeat-containing protein 2 (BIRC2), baculoviral IAP repeat-containing protein 3 (BIRC3), and TNF receptor-associated factor 3 (TRAF3). This evidence concerns the gene BIRC3 and neoplasm.