SREBF1 and rectal cancer: In rectal cancer, the SREBP1/FASN signaling pathway is activated rapidly under radiation stimulation, leading to cholesterol accumulation, cell proliferation, and inhibition of apoptosis, and blocking the SREBP1/FASN pathway hinders cholesterol synthesis and accelerates radiation-induced colorectal cancer cell death, which could be a potential target for colorectal cancer therapy [89].