Key enzymes regulated by SREBP-2, such as 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGCR) and mevalonate kinase (MVK), as well as key pathways mediated by SREBP-2, such as p53 and the phosphatidylinositol-3 kinase (PI3K)/Akt signaling pathway, are involved in the progression of many cancers [86]. The gene discussed is HMGCR; the disease is cancer.