ACSL4 is different from other long-chain lipoyl-coenzyme family members in that which preferentially activates arachidonic acid (arachidonic acid, AA) and eicosapentaenoic acid to form long-chain polyunsaturated lipoyl-coenzyme A. Over-expression of ASCL4 would up-regulate intracellular long polyunsaturated lipoyl-CoA levels and increase the oxidized phospholipid content on the membrane surface, thereby increasing the sensitivity of tumor cells to ferroptosisinducers. The gene discussed is ACSL4; the disease is neoplasm.