SREBP1 is a downstream target of ACSL4 and is essential for ACSL4-mediated tumor growth and metastasis, c-Myc activates and cooperates with SREBP1 to induce genes involved in FA synthesis, ACSL4 up-regulates lipogenic enzymes through the c-Myc/SREBP1 signaling pathway to regulate lipid metabolism and provide new insights into the treatment strategy of hepatocellular carcinoma [83,84]. This evidence concerns the gene ACSL4 and hepatocellular carcinoma.