LCN2 and hilar cholangiocarcinoma: Nair et al. [4] suggest that neutrophil gelatinase-associated lipocalin (NGAL) can be considered as a diagnostic biomarker for perihilar cholangiocarcinoma (PHC) and potentially for developing targeted therapeutics, while Tung et al. [5] supported that using miRNAs as a diagnostic biomarker for colon adenocarcinoma (COAD) has led to a potential targeted drug (Gemcitabine) for this type of gastrointestinal cancer.