VAV1 and breast neoplasm: On the other hand, the expression of Akt2 significantly increased only in HBCx-9, in which the silencing of Vav1 diminished miR-29b expression (Figure 5A), demonstrating the existence of a Vav1/miR-29b/Akt2 axis in some breast tumor cells with a triple negative phenotype, apparently unrelated to a specific molecular subtype.