In psoriatic cells and animal models, overexpression of RAS-association domain family 1A (RASSF1A) or inhibition of promoter methylation with the methylation inhibitor 5-Aza-CdR reduced YAP expression; inhibited cell proliferation; induced G0/G1 cell cycle arrest; increased the apoptosis rate; decreased the expression of inflammatory cytokines; decreased the activity of the AKT, ERK, STAT3, and NF-κB signaling pathways; and improved skin lesions in mice, indicating that RASSF1A may be an upstream negative regulator of YAP in psoriasis [57]. This evidence concerns the gene YAP1 and psoriasis.