Patients with CRSwNP have a Th2-predominant type of inflammation and present high levels of interleukin-5 (IL-5) and eosinophilic inflammation, an image that is often also seen in severe asthma, where the aforementioned mAbs are also used with great efficacy [9,10]. This evidence concerns the gene IL5 and chronic rhinosinusitis with nasal polyps.