Several mechanisms may explain the association between obesity and hypertension, including a physical compression effect of visceral and retroperitoneal fat on the kidneys, increased SNS activity, activation of the renin-angiotensin-aldosterone system (RAAS), and also metabolic disorders (including insulin resistance, dyslipidemia, and inflammation) [8,10]. This evidence concerns the gene REN and obesity due to melanocortin 4 receptor deficiency.