ACE2 and COVID-19: Considering the deleterious impact of ACE/Ang II/AT1R pathway activation, along with the beneficial effects of the ACE2/Ang 1-7/MasR pathway in lung protection, several therapeutic strategies were recommended, such as recombinant human ACE2 (rhACE2), Ang 1-7 analogs, a combination of rhACE2 and remdesivir, etc., which could enhance the activity of ACE2, and consequently to combat the progression of COVID-19 [15].