Other cell surface glycoproteins and interleukins identified in the RegLP cluster are important for a range of T cell functions, for example, the following: CD7 is a differentiation marker for CD8+ T cells [31]; CD5 downregulation potentiates T-cell antitumour activity [32]; IL4, IL13, IL5 locate in a cytokine gene cluster on chromosome five and regulate multiple immune cell functions, including in T helper 2 cells [33,34]; IL17A is produced by activated T cells where it may impact many processes, notably promoting tumour progression [35,36]. This evidence concerns the gene IL4 and neoplasm.