In a mouse model, GNAI1 and GNAI 3 suppressed DSS-plus-azoxymethane-induced colon tumor development, whereas the expression of GNAI2 in CD11c+ cells and interleukin-6 (IL6) in CD4+/CD11b+ dendritic cells appeared to promote these effects. This evidence concerns the gene GNAI1 and colonic neoplasm.