The extensive functions and interactions of TRAF3 are still being elucidated, but it is known to be important to inflammatory pathway signaling and gene abnormalities have been associated with many diseases including herpes simplex encephalitis (IIAE5, OMIM 614849), Waldenstrom macroglobulinemia (WM, OMIM 153600), and IBD. Here, TRAF3 is linked to Waldenstrom macroglobulinemia.