As shown in Figure 7D, cancer cell lines including HCC827 (del E746-A750 in exon 19), HCC2279 (del E746-A750 in exon 19) and HCC4006 (del E746-A750 in exon 19) have higher levels of ADAMTS8 expression than in TKI-resistant cancer cell lines (H1650 (del E746-A750 in exon 19) and H1975 (L858R in exon 21)). Here, ADAMTS8 is linked to cancer.