In AD, inflammation is linked to elevated levels of inflammatory cytokines, including T2-associated IL-4, -13 [30,31], -31, but also IL-22, Th17, and Th1-associated interferon-gamma, with downstream activation of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway [32]. This evidence concerns the gene IL4 and Alzheimer disease.