FLG and Alzheimer disease: Loss-of-function mutations in the filaggrin gene do not increase the risk of food or aeroallergen sensitivity independently of AD status [68,69], suggesting there must be other important genetic and/or environmental modifiers such as allergens, environmental pollutants, and oxidative stress that are required for the development of allergic skin inflammation, generalized T2 inflammation, and progression of the atopic march [8,70].