In the same way, variants are also related to a worse prognosis with higher risk of refractoriness and relapse in AML, such as WT1 [58,59,60], or with a favourable outcome related to a better treatment response, such FBXW7 and NOTCH1 in T-ALL [61,62,63]. The gene discussed is WT1; the disease is acute myeloid leukemia.