In addition to these functions, IL-6 plays an important role in various metabolic processes as autocrine and/or paracrine actions of adipocyte function [123] and is closely linked to MetS favoring the onset of insulin resistance, elevated glucose production in the liver, inhibition of the insulin-mediated glucose uptake in skeletal muscle, and facilitating the onset of hypertension [124]. The gene discussed is INS; the disease is metabolic syndrome.