DUX4-targeting miRNAs were shown to reduce DUX4 mRNA and protein in a DUX4-overexpression mouse model [69,70], and U7 antisense DUX4 snRNAs reduced levels of DUX4 and its targets in cultured FSHD myocytes [71]. This evidence concerns the gene DUX4 and facioscapulohumeral muscular dystrophy.