The study showed that a 10-gene signature (C1QA, C1QB, C1QC, CD86, C3AR1, CSF1R, ITGB2, LCP2, SPI1, and TYROBP) was linked to M2 macrophage in the tumour microenvironment (TME) and poor prognosis in ESCC that expresses those genes (HR: 2.104, p = 0.001). Here, C3AR1 is linked to neoplasm.