We also identified six variants of five genes that we associated with susceptibility to ALL (CDKN2A_rs11515, PIP4K2A_rs2765997 and rs1053454, IGF2BP1_rs8068981, WWOX_ rs3764342, and USP7_rs2304465) given the significant differences in the frequencies recorded in the two Amerindian groups (ALL patients and cancer-free individuals), and between the ALL group and populations of other groups from around the world. Here, IGF2BP1 is linked to cancer.