The positive biological effects of fibers and acetate were ascribed to: (i) the downregulation of cardiac and renal genes for early-growth-response-protein-1 (Egr1), involved in myocardial hypertrophy, fibrosis, and inflammation; (ii) the downregulation of the renin–angiotensin system in the kidney [26]. The gene discussed is EGR1; the disease is cardiac hypertrophy.