THs control the transcription of target genes implicated in cancer either directly or indirectly by regulating several signaling pathways positively (e.g., PI3K/Akt, endoglin, sonic hedgehog (SHH), RAS-ERK, microRNA-21) or negatively (e.g., ubiquitin-like with PHD and ring finger domains 1 (UHRF1)), or either positively or negatively (e.g., Wingless/Int (Wnt)/β-catenin). Here, UHRF1 is linked to cancer.