The precise mechanisms linking cognitive performance and obesity have not yet been identified, although altered brain structure, blood–brain barrier and leptin regulation, poorer cerebrovascular function and blood flow cerebral perfusion, arterial hypertension, oxidative stress, and inflammation have also been implicated [80,85,86,87,88,89,90,91,92]. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.