EGFR and non-small cell lung carcinoma: The purpose of this study was to perform a systematic review and meta-analysis of currently available clinical trials to evaluate the efficacy of combination treatment using EGFR-TKIs and anti-angiogenic agents and to analyze the impact of smoking status among advanced-stage NSCLC patients who harbor EGFR mutations when treated with EGFR-TKIs alone or in combination with anti-angiogenic agents