EGFR and non-small cell lung carcinoma: Recently, two trials presented at the European Society of Medical Oncology (ESMO) in 2021 failed to show clinical benefits for the combination of osimertinib and bevacizumab in NSCLC patients who harbor EGFR mutation when used as either a first-line (WJOG 9717L) [29] or second-line (ETOP 10-16 BOOSTER) [30] regimen, but both trials showed a significant improvement in PFS when combination therapy was used in the ever smoker subgroup.