Besides the anti-CTLA4 and anti-PD-1/PDL-1 axis, several other inhibitory molecules are expressed by T-cells in the tumor micro-environment, such as lymphocyte activation gene-3 (LAG-3), T-cell immunoglobulin and mucin domain (TIM-3), or T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domains (TIGIT). The gene discussed is LAG3; the disease is neoplasm.