Mazzella et al. published observations in family members with a TGFBR2 frameshift mutation (Loeys–Dietz syndrome type 4) who suffered from diffuse vascular lesions, e.g., intracranial aneurysms, medium-caliber artery dissection, aortic and iliac aneurysms [40]. This evidence concerns the gene TGFBR2 and Dilatation of the cerebral artery.