This work is an extension of current research [3], in which we present new changes in the genes related to Alzheimer’s disease, such as the amyloid protein precursor, β-secretase, presenilin 1, and presenilin 2, in the circulating lymphocytes of neonates with perinatal asphyxia treated with hypothermia. The gene discussed is APP; the disease is early-onset autosomal dominant Alzheimer disease.