In the same year, and with a sample size of 16,851 cases and 32,473 non-stroke controls, the NINDS Stroke Genetics Network (SiGN) [6] found a new locus associated with LAS close to TSPAN2 and confirmed the previous loci ABO, HDAC9, PITX2, and ZFHX3. This evidence concerns the gene PITX2 and Stroke.