In these studies, IgG from atopic individuals could modulate the production of IFN-γ by TCD4 and TCD8 cells [27], IgG from AD patients modulated the production of IL-17 and IL-10 by TCD4 and TCD8 cells [28], and IgG from HIV-1-exposed noninfected individuals modulated the production of IFN-γ by thymic TCD4 and TCD8 cells [29]. This evidence concerns the gene IFNG and Alzheimer disease.