ICR mice and SR rats with loperamide (Lop)-induced constipation exhibited a decrease in the level of two ICC markers (C-kit and SCF) and the other enteric nerve-related factors (PGP9.5, brain-derived neurotrophic factor (BDNF), and GNDT) [33,34]. The gene discussed is UCHL1; the disease is intrahepatic cholangiocarcinoma.