More importantly, we have recently reported that bitter melon extract (BME) and its bioactive protein Momordica anti-HIV protein (MAP30) function as a natural AMPK activator inducing AMPK activity through CaMKKβ signaling in an AMP-independent manner, which in turn inhibited both mTOR/p70S6K and AKT/ERK/FOXM1 signals in ovarian cancer cells (Figure 1). This evidence concerns the gene PRKAA1 and ovarian cancer.