Genes such as zinc finger protein 99 (ZNF99), a gene found to be mutated in NSCLC with resistance to etoposide [51], and FLG, a highly mutated driver gene found in lung cancer [52], GPRIN2 and PCDHB13 that has been found to be downregulated in NCSLC and that negatively correlated with pathological grade [53], were mutated in all treated samples in both cell lines with a 100% mutation rate. The gene discussed is FLG; the disease is lung cancer.