The PLA2 family members, which were identified in human placental tissue and appear to be involved in the aberrant lipid metabolism of pregnancies complicated by preeclampsia (PE) or obesity, are PLA2 group IIA (PLA2G2A) and PLA2 group V (PLA2G5) (Table 1). Here, PLA2G5 is linked to obesity due to melanocortin 4 receptor deficiency.