The PLA2 family members, which were identified in human placental tissue and appear to be involved in the aberrant lipid metabolism of pregnancies complicated by preeclampsia (PE) or obesity, are PLA2 group IIA (PLA2G2A) and PLA2 group V (PLA2G5) (Table 1). The gene discussed is PLA2G6; the disease is obesity due to melanocortin 4 receptor deficiency.