This was an observational study that used Flatiron Health’s HER database from 255 US cancer clinics and included advanced melanoma (n = 66) and NSCLC patients (n = 241) who received denosumab within 30 days of CTLA4 (ipilimumab) or PD1 (pembrolizumab, nivolumab) inhibitors (in NSCLC cohort only 21.6% treated in first-line). The gene discussed is CTLA4; the disease is non-small cell lung carcinoma.