Notably, these mutations are rarely found in corticotrope adenomas, with a reported prevalence of 6.2–6.3% of examined adenomas, whereas glucocorticoid resistance is one of the hallmarks of Cushing’s disease, implying that GR dysfunction has a pivotal role in its pathophysiology, regardless of NR3C1 mutational status [38]. The gene discussed is NR3C1; the disease is adenoma.