This may be supported by some case series that report relevant clinical differences in patients with USP8-mutated compared to USP8-WT adenomas (e.g., higher prevalence in females, smaller size, lower rates of parasellar invasion, better post-surgical outcomes but higher rates of recurrences) [8,9,12,30,31,32,33,34], although with conflicting results [16,18,26,32,33,34]. This evidence concerns the gene USP8 and adenoma.