POMC and adenoma: Ma et al. conducted a DNA exome sequencing of 12 fresh tumor samples and the additional Sanger sequencing of DNA samples from 108 other ACTH-secreting adenomas, finding USP8 mutations in 62.5% adenomas (75/120) [8]; Reincke et al. performed tumor DNA exome sequencing on 10 samples and USP8-targeted sequencing on an additional seven samples, finding an overall prevalence of 35% (6/17) [9].