In an in-depth study by de Kock et al., germline DICER1 mutations were found in nine children affected by pituitary blastoma, with the other allele presenting somatic non-synonymous mutations (six cases) or loss of heterozygosity (one case) in the tumoral tissue, suggesting a potential two-hit model for the tumorigenesis of pituitary blastomas in DICER1 syndrome [100]. Here, DICER1 is linked to DICER1-related tumor predisposition.