USP8-mutated corticotrope adenoma cells are more sensitive to corticotrope modulators, namely CRH and dexamethasone, in vitro, compared to USP8-wild-type (WT) ACTH-secreting adenomas, with higher levels of CRH and glucocorticoid (NR3C1) receptors [15]. This evidence concerns the gene USP8 and adenoma.