Germline mutations in SDHA, SDHB, SDHC, and SDHD (collectively, SDHx) are associated with the development of PRL- and GH-secreting adenomas, pheochromocytomas, and/or paragangliomas, a syndrome named 3P association. The gene discussed is SDHC; the disease is hereditary pheochromocytoma-paraganglioma.