CRH and adenoma: Interestingly, a coexisting mutation of the RASD1 gene has been reported in a case of USP8-mutated adenoma [23]; a murine model supports the hypothesis that RASD1 is induced by dexamethasone in corticotrope cells and likely plays a role in glucocorticoid-mediated negative feedback functioning as an inhibitor of the CRH signaling pathway [24].