In brief, this study is the first to find circDCLRE1C to be significantly upregulated in chicken coccidiosis, along with dramatically aggravated macrophage inflammation by sponging miR-214b-3p target sites and modulating STAT3 expression, and that circDCLRE1C is an upstream regulator of STAT3. This evidence concerns the gene STAT3 and coccidiosis.