Inflammation-related pathways (NF-κB and Stat3), BCSC microenvironment and tumor hypoxia (TGF-β and HIF), proliferative pathways (HER2 and PI3K/Akt) and the loss of tumor suppressor (BRCA1) also contributed to the stem cell properties in BCSCs [9,60]. This evidence concerns the gene NFKB1 and neoplasm.