RAPGEF3 and breast carcinoma: For this reason, amine–PEG has been used to functionalize GO with the purpose of delivering various miRNAs and siRNAs to breast cancer cells, including: (1) miRNA 101 and Rictor siRNA, which are regulators of the PI3K/AKT pathway and responsible for cell metabolism and proliferation; (2) EPAC1 siRNA to inhibit EPAC1 protein, which is responsible for cell metastasis; (3) cell death (cd) siRNA to induce apoptosis; (4) P-gp siRNA to inhibit multidrug resistance protein (P-gp) [17,62,67,70,88].