The most common experimental animal model for this disease is experimental autoimmune encephalomyelitis (EAE), which is induced by immunization with CNS tissue or myelin peptides, such as MOG, myelin basic protein (MBP), and proteolipid protein (PLP) in complete Freund’s adjuvant (CFA) [82]. The gene discussed is MOG; the disease is experimental autoimmune encephalomyelitis.