Stroke: Right side pMCAO using a small 6–0 siliconized monofilament. AD: 3xTransgenic mice harbored 2 mutant human transgenes (APP Swedish mutation and tauP301L)—driven by neuron-specific Thy1-regulatory elements—added by the homozygous knock-in construct presenilin-1M146V. The gene discussed is APP; the disease is Alzheimer disease.