The phosphatidylinositol-3-kinase (PI3K)/Akt and the mammalian target of rapamycin (mTOR) signaling pathways have been proposed to be implicated to play a crucial role in the pathogenesis of systemic sclerosis (SSc)—in particular, in two critical aspects, fibrogenesis and B-cell activation [1,2], which are two typical features of SSc [3]. Here, MTOR is linked to systemic sclerosis.