In August 2019, Entrectinib reached FDA accelerated approval for advanced solid tumors with NTKR fusions and for metastatic ROS1-positive NSCLC based on the results of three multicenter, single-arm, clinical trials (STARTRK-1, STARTRK-2, ALKA-372-001) [71]. This evidence concerns the gene ROS1 and non-small cell lung carcinoma.