VCP and amyotrophic lateral sclerosis: In humans, autosomal-dominant mutations in the VCP gene cause severe multisystem degenerative diseases such as inclusion body myopathy associated with Paget’s disease of the bone and frontotemporal dementia (IBMPFD), amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), or myofibrillar myopathies (MFMs) [4,5,6,7,32]].