Consequently, the present STZ-induced diabetic study has to add a cautious note that any beneficial actions of exercise on cerebral cortex changes cannot be isolated to one specific factor or any specific system but may be affected directly or indirectly by various factors, such as hyperglycemia, oxidative stress, inflammatory, endocrine, skeletal muscle produces bioactive molecules (such as interleukin-6, tumor necrosis factor-α) to communicate to other organs (brain, circulatory system, adipose tissue, etc.), or unclear interacting factors. This evidence concerns the gene TNF and Hyperglycemia.