The constitutive activation of STAT3 signal promotes the growth, survival, angiogenesis and metastasis of tumor cells [41]; the overexpression of abnormally acetylated (activated) TF STAT3 can upregulate its target gene HIF1A [42], thereby promoting cellular functions, including cell proliferation as well as autophagy and inhibiting apoptosis [43]. This evidence concerns the gene TF and neoplasm.