NFE2L2 and age-related macular degeneration: In an experimental model of age-related macular degeneration (OXYS rats with signs of age-related macular-degeneration-like retinopathy of varying severity), it has been found that an imbalance between the prooxidant (AhR-dependent) system and antioxidant (Nrf2-dependent) system may be key to the pathogenesis of age-related macular degeneration and its initiation and/or progression [265].