An essential regulator of inflammation associated with metabolic syndrome is the nucleotide-binding domain, leucine-rich-containing family, pyrin domain containing-3 (NLRP3) inflammasome, which activates caspase-1, after interacting with the adaptor protein apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain (ASC). This evidence concerns the gene NLRP3 and metabolic syndrome.