As expected, synergism was observed when combining BET inhibitors (e.g., BAY 1238097, GS-5829, OTX015) with inhibitors of BTK (ibrutinib), SYK (entospletinib), PI3K (copanlisib, idelalisib), or BCL2 (venetoclax) in preclinical models of CLL [32,33,34] and DLBCL-RT [35]. The gene discussed is PIK3CG; the disease is diffuse large B-cell lymphoma.